And he once again starred for the Spurs to down the Suns in a stunning last-gasp comeback.
Wembanyama scored 18 points, had eight rebounds and four blocks as the Spurs came back from 20 points down in the third quarter to claim the 115-114 win.
Coming off a brutal 40-point mauling by the LA Clippers on Sunday, San Antonio looked to be heading for another heavy defeat until the Spurs outscored the Suns 33-19 in the final frame to secure victory.
French prodigy Wembanyama, the No. 1 NBA Draft pick, played a crucial role in the comeback, with a jump shot from 15-feet, making it a three-point game with 49 seconds left on the clock.
He then tipped in a dunk to make it a one-point game with seven seconds remaining.
The decisive play however came from forward Keldon Johnson, who wrestled the ball away from a stunned Durant before driving to the basket for a layup that handed San Antonio their first lead of the game with just two seconds remaining.
There was still time for Durant to launch an attempted buzzer-beater, but his shot missed to leave San Antonio celebrating their first road win of the season.
“It wasn’t our prettiest game but we’re learning every day and we’re on the right path,” Wembanyama told broadcaster TNT after the win.
Spurs coach Gregg Popovich saluted his team’s ability to keep grinding away in search of a victory.
“We made a gazillion mistakes – but it’s a game of mistakes. And so does every team,” Popovich said.
“But we just kept playing and that’s the best thing about the group. I was really proud of them.”
Wembanyama was one of five San Antonio players who finished in double figures. Johnson led the game in scoring with 27 points.